Sodium salicylate produces irreversible inhibition of the cyclo-oxygenase step of arachidonic acid metabolism, leading to a suppression of prostaglandin production in all metabolic systems. The duration of action allows a twelve hour dosage regime for inflammatory conditions. Thrombosis inhibition requires administration every 2 – 7 days, depending on the dose.
SALSPRIN is indicated for the control of fever and/or pain, as well as for control of inappropriate thrombosis in the horse and dog. Salicylate has a half-life of 1 hour in the horse, and 8.6 hours in the dog,and is rapidly cleared from the body. Onset of action is approximately 10 – 15 minutes. The pharmacological effects of the salicylate are, however,considerably more prolonged than this, due to the irreversible nature of the action. This allows a 12 hour dosing regime for inflammatory conditions. SALSPRIN will not control severe visceral pain, or sharp or excruciating pain due to severe wounds or fractures. Musculo-skeletal: Short term treatment of mild joint and connective tissue disease, osteoarthritis, tendon and ligament sprains, and exertional myopathy. Pyrexia: Symptomatic suppression of fever in situations where the pyrexia is inappropriate or excessive. Thrombosis: Prevention or reduction of thrombosis when it plays a part in disease aetiology (such as pedal thrombotic conditions), early disseminated intravascular coagulation -DIC- in horses and dogs, and as an adjunct to Dirofilaria immitis adulticide therapy in dogs.
DOSAGE AND ADMINISTRATION
Horse: 35 – 45 mg/kg every 8 – 12 hours by slow intravenous injection
Dogs: 10 mg/kg every 12 hours by slow intravenous injection
SALSPRIN should not be administered to animals less than 30 days old, or to animals with severe renal or hepatic disease.
SALSPRIN should not be administered less than 7 days before surgery, or to those animals known to suffer from clotting defects.
Do not use when intestinal ulceration is suspected or has been diagnosed.
Do not use concurrently with aminoglycoside antibiotics.
Administer by slow intravenous injection. Avoid extravasation as irritation and phlebitis may result.
Meat Withholding Period (Horses): 28 Days.