Description
Pentosan Gold Injection for Horse contains Pentosan Polysulfate
Sodium (PPS) which stimulates joint healing and repair, and reduces
inflammation to help reverse the effects of osteoarthritis, as well as
NAG (Acetyl Glucosamine) a newly approved and more advanced form
of glucosamine that has been shown to improve glycosaminoglycan
and hyaluronic acid synthesis compared to glucosamine (Shikhman
AR et al 2009). Pentosan Gold possesses anti-inflammatory, anti-
arthritic and chondroprotective properties. These beneficial effects
arise from direct anti-inflammatory activity, inhibition of neutrophil
migration into joints, stimulation of hyaluronic acid synthesis by
synovial fibroblasts which results in a marked increase in synovial fluid
volume and viscosity; stimulation of chondrocytes, and the biosynthesis
of proteoglycans; and a strong fibrinolytic activity which improves the
circulation in subchondral bone and periarticular structures.
Treatment using the combination of anti-arthritic agents Pentosan
Polysulfate Sodium and NAG (Acetyl Glucosamine) in Pentosan Gold
may result in a greater anti-inflammatory effect than either active
alone (Heinecke LF et al 2010, Data on File), which helps reduce joint
swelling and improve mobility (Data on File).
A field trial was conducted to compare the response to PPS along
with Pentosan Gold (PG) in horses. Twenty one field cases, presented
to veterinarians for joint disease were used. In this trial the response
to PG was superior to PPS alone when treating the symptoms of
osteoarthritis. The improvements in the measured variables, response
time, effusion, flexion and overal response were higher for PG than for
PPS indicating a greater anti-arthritic effect overall. This difference was
significant for overall response, with 91% of horses having a “very good”
or “good” response to PG compared to only 33% with a “very good” or
“good” response for PPS. The response time was also significantly faster
for PG, with horses responding within 1.7 weeks compared to 2.4
weeks for PPS. There was a tendency for a greater improvement in the
flexion response with PG, with 66.6% horses showing an improvement
compared to only 20% with PPS. Also there were a larger number
of horses which showed reduced joint effusion for PG, 89% overall
compared with 37.5% for PPS. Overall horses treated with Pentosan
Gold showed greater improvements in the symptoms of joint disease
than horses treated with PPS alone (McConaghy and Perkins 2012).
INDICATIONS
To aid in the treatment of non-infectious, inflammatory joint disease in
horses. In particular :
1. Osteoarthritis – especially with involvement of multiple joints
2. Osteochondrosis dissecans
3. Traumatic joint and peri-articular inflammation
DOSAGE AND ADMINISTRATION
3 mg/kg Pentosan polysulfate sodium, 4.8 mg/kg Acetyl-Glucosamine
(12 mL/500 kg horse) on four occasions with an interval of 5-7 days
between injections.
Administer by intramuscular injection.
Contraindications: Use in horses with clotting defects, traumatic
haemorrhage, infection, liver/kidney failure or within 2 days of surgery.
Should not be administered to horses within 24 hours of high stress
activities or where physical injury may occur. Avoid concurrent
treatment with anticoagulant drugs.
Meat Withholding Period (Horses): 28 Days.
