Lactanase Injection

Enzymic modulator to reduce lactic acid accumulation and delay muscle fatigue

COMPOSITION
Contains:
Dichloro-acetic acid 120 µg/mL
Sodium gluconate 250 mg/mL

ACTIONS
Lactanase contains dichloroacetic acid, which is an activator of the enzyme pyruvate dehydrogenase. This enzyme plays a central role in the process of lactic acid production during hard work.

Supplementation with dichloroacetic acid (DCA) results in activation of the enzyme pyruvate dehydrogenase, leading to a reduction in the rate of lactic acid production and accumulation in muscles.

Elevated plasma lactate levels result in a reduction in pH which contributes to muscle fatigue and decreased muscle performance.

Supplementation with DCA has been shown to reduce lactic acid accumulation during exercise, and produce a significant delay in
muscle fatigue.

The pathogenesis of Exertional Rhabdomyolysis (“Tying Up”) in horses is related to lactic acidosis during exercise, and associated low muscle pH.

Sodium bicarbonate and dimethylglycine (DMG), which may help to reduce lactic acid accumulation during exercise, have been used to assist in the prevention of Tying Up in horses. Similarly, DCA (Lactanase) results in a reduction in the rate of lactate accumulation, and a delay in the onset of muscle fatigue.

INDICATIONS
To help reduce the incidence of Tying Up by reducing the build-up of lactic acid in muscle cells.

DOSAGE AND ADMINISTRATION
Administer intravenously via a catheter or dilute in 1 L saline before administration.
Adult Horse: 20-40 mL
Administer once weekly for 4 weeks then discontinue for 4 weeks
before repeating the course.

WARNINGS
Take care to avoid leakage from the vein. Lactanase is highly irritant if given outside the vein. Avoid accidental contact with mucous membranes or eyes (avoid accidental spillage or spray).

Meat Withholding Period: NOT TO BE USED in horses that may be slaughtered for human consumption.

PRESENTATION
100 mL sterile glass multidose vial.

STORAGE
Store below 25˚C (Air Conditioning). Protect from light.

AVAILABILITY
By Veterinary Prescription Within Australia, Lactanase is a Prescription Only Remedy, manufactured under Permit, and available for sale only to registered veterinary surgeons.

SEE ALSO
L-carnitine, Physine, Green Amino Powder, DMG, Tripart, Tridenosen, AMP-5, Untie

SPECIES: equine


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