Joint Guard Plus

Oral Joint Supplement with Hyaluronic Acid, Glucosamine and Chondroitin Sulfate

COMPOSITION
Each 20 g contains: Glucosamine Hydrochloride 10,000 mg
Sodium Chondroitin Sulfate 600 mg
Sodium Hyaluronate 125 mg

Also contains: Methyl Sulfonyl Methane 3,500 mg
Manganese Gluconate 65 mg, Zinc 31.8 mg, Copper 4 mg, Calcium
Ascorbate (Vit C) 116 mg, Vitamin E 40 mg

ACTIONS
Many Australian equine oral joint supplements contain glucosamine and chondroitin sulfate, however Joint Guard Plus is unique in its combination of high levels of glucosamine with sodium hyaluronate in an oral powder form.

Glucosamine is utilised in the production of glycosaminoglycans (GAGs) which then combine with hyaluronic acid (HA) to form large proteoglycans in the matrix of cartilage. As such, glucosamine is a fundamental building block of the cartilage structure, and a growing body of evidence supports the pain-relieving and potentially chondroprotective properties of glucosamine.

Joint Guard Plus contains high levels of glucosamine (500 mg/g) to counteract the limited oral bioavailability of glucosamine in
horses.¹, ² The current recommended dose of oral glucosamine for horses is 10,000 mg per day.³

Chondroitin Sulfate (CS) is another fundamental building block of joint cartilage and oral administration in combination with glucosamine has demonstrated positive effects on equine
osteoarthritis.¹, ² Molecular weight markedly affects CS absorption in horses¹ and Joint Guard Plus contains a low molecular weight CS with proven, rapid oral bioavailability.

Sodium Hyaluronate, the sodium salt of hyaluronic acid (HA), is present in many body tissues including connective tissue and skin and in synovial (joint) fluid in very high concentrations. HA provides visco-elastic properties to joint fluid and functions as a lubricant.

In joint disease, inflammation breaks down HA which results in lowered viscosity of the joint fluid and further influx of inflammatory cells, exacerbating cartilage damage and joint disease.

Supplementation with Sodium Hyaluronate helps to replace HA lost as a result of joint disease and thereby restores lubrication of the joint, reduces inflammatory infiltrates and minimises ongoing damage.

Oral Administration – Trials (including several at Rood and Riddle Equine Hospital, Kentucky, USA) have shown benefits in the use of oral HA in horses which include positive effects on lameness incidence and severity, synovial effusion and inflammation, joint pain and improvement in pre-existing joint conditions.5,6,7

Circulating HA has a half-life of 2 days or less, necessitating daily supplementation to maintain long-term elevation of serum HA.6

Methyl Sulfonyl Methane (MSM), a metabolite of dimethyl sulfoxide (DMSO), has been shown to help relieve joint pain associated with osteoarthritis in humans8 and is recommended for managing horses with osteoarthritis.9

INDICATIONS
Long term treatment with Joint Guard Plus may help improve joint function.

DOSAGE AND ADMINISTRATION
Adult Horse (500 kg): Administer one 20 g scoop daily. [Each 1.5 kg bucket provides 75 daily doses of 20 g]

Add powder to moistened feed. Long-term treatment is required.

WARNINGS
Export Slaughter Interval (Horses): Nil

PRESENTATION
Powder: 1.5 kg bucket

STORAGE
Store below 30˚C (Room Temperature) in a dry place. Replace lid tightly after use

AVAILABILITY
This product is NOT REGISTERED and is available under APVMA Permit No. 11494 to registered veterinary practitioners for use under their direction on animals in their care. The Efficacy and
Safety of this product has not been assessed by the APVMA.

REFERENCES
1.Du et al, Biopharm Drug Dispos 2004;25:109-116 2.Laverty et al, Arthritis Rheum 2005;52:181-
191 3.Oke et al, AAEP Proc. 2006;52:574-579 4.Eddington et al, AAEP Proc. 2001;47:326-328
5.Bergin et al, Equine Vet. J. 2006;38:375-378 6.Pierce S., 3 unpublished studies (Rood & Riddle
Equine Hospital, Kentucky, USA) 7.Contipro laboratories, unpublished data 8.Usha et al, Clinical
Drug Investigation 2004;24(6):353-363 9.Jones WE, J Eq Vet Sci 2000;20:160-163/217-218

SPECIES: equine


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