GEN 10

Broad-spectrum Antibiotic for Chicken, Turkey, Dogs, Cats, Piglets, Horses & Cows

DESCRIPTION:
GEN 10 is a broad-spectrum antibiotic for use in chicks, turkey poults, cats, piglets, dogs, cows & horses.

Gentamicin sulfate veterinary is a bactericidal aminoglycoside antibiotic derived from Micromonospora purpurea of the Actinomycetes group. It is a powder, readily soluble in water and basic in nature. Gentamicin aqueous solutions do not require refrigeration and are stable over a wide range of temperatures and pH.

INDICATION:
GEN 10 solution is clinically effective in infections due to suspectible gram-negative & gram-positive bacteria, including Pseudomonasaeruginosa, indole negative & indole positive Proteus species, Escherichia coli, Klebsiella pneumonia,Enterobacter aerogenes, Arizona hinshawii and Staphylococcus species. The use of GEN 10 Solution is indicated in the treatment of infections caused by laboratory determined suspecptible bacteria, with due regard for relative antibiotic toxicity. Therefore, the drug should be considered as follows:

Indication Route Species
1. Urinary tract infections (cystitis and nephritis). I.M./S.C. Dogs & Cats
2. Bacteremia/Septicaemia. I.M./S.C. Dogs & Cats
3. Infected wounds. I.M./S.C. Dogs & Cats
4. Soft tissue infections. I.M./S.C. Dogs & Cats
5. Respiratory tract infections. I.M./S.C. Dogs & Cats
6. Gastrointestinal tract infections. I.M./S.C. Dogs & Cats
7. Scours (Escherichia coli) I.M./S.C. 1-3 days old piglets
8. Uterine infections:
a. Bacterial infections of the uterus (metritis) I.U/I.M Dogs
b. Bacterial infections oft the uterus (metritis) I.U Horses
c. Metritis and cervitis associated with bacteria
such as E. coli, S. aureus and Streptococcus
species which are susceptible to gentamicin.

The method of treatment of metritis associated with systemic involvement should be at the discretion of the attending veterinarian.

-As an aid in the prevention of mortality in the first two weeks of life of 1 to 3 day old turkey poults due to Arizona hinshawii infections – S.C.
-Prevention of early mortality caused by Escherichia coli, Salmonella typhimurium, and pseudomonas aeruginosa susceptibile to gentamicin.

ACTIVE INGREDIENTS PER ML ACTION
Gentamicin (as Gentamicin Sulfate) 100 mg Antibiotic

NON-ACTIVE INGREDIENTS PER 100ML ACTION
Sodium Metabisulfite 0.24 g Antimicrobial Preservative
Sodium Sulfite 0.08 g Antimicrobial Preservative
Benzoic Acid 1.0 g Antimicrobial Preservative
EDTA-2Na 0.07 g Buffer
Water Q. S. Buffer

DOSAGE AND ADMINISTRATION:
Chickens:
Each day-old chicken should be aseptically injected subcutaneously in the neck with GEN 10 Injection diluted with sterile, physiologic saline solution to provide 0.2 mg gentamicin in a 0.2 mL dose. This concentration can be provided by diluting GEN 10 as follows:

GEN 10 Sterile
Saline Dose/Chicken
mL mL # Doses mL
1 99 500 0.2
2 198 1000 0.2
4 396 2000 0.2
10 990 5000 0.2
100 (1 bottle) 9900 50000 0.2

Turkeys:
Each 1- to 3-day-old turkey should be aseptically injected subcutaneously in the neck with GEN 10 Injection diluted with sterile, physiologic saline solution to provide 1 mg gentamicin in a 0.2 mL dose. The dose should be injected under the loose skin on top of the neck, halfway between the head and base of the neck. This concentration can be provided by diluting GEN 10 as follows:

GEN 10 Sterile
Saline Dose/Turkey
mL mL # Doses mL
1 19 100 0.2
2 38 200 0.2
4 76 400 0.2
10 190 1000 0.2
100 (1 bottle) 1900 10000 0.2

Dogs and Cats:
Administer intramuscularly 4.4 mg/kg twice the first day and once a day thereafter. To facilitate administration in small dogs and cats, dilute 0.5 ml (50 mg) GEN 10 with 2 ml of sterile water. The resulting solution will have a concentration of 20 mg/ml. Inject 1 ml of the solution for 4.54 kg (10 lbs) of body weight to achieve the recommended dosage rate of 4.4 mg/kg. The average duration of treatment is 7 days. If the case is not responsive in 7-10 days, re-assess the diagnosis and conduct sensitivity tests. When treating urinary tract infections, alkalinization of the urine may be good adjunctive therapy.

Piglets:
Administer intramuscularly. Inject once with 5 mg gentamicin for a 1-3 day old piglet. Dilute 2.5 ml gentamicin with 47.5 ml of sterile water and give each piglet a dosage of 1 ml (1 ml contains 5 mg gentamicin).

Horses:
1.5 mg/kg every eight hours. Give by sterile subcutaneous, intramuscular or intravenous injection.
MaresIntra-uterine infusion 2.5 g, diluted in 400 mL sterile normal saline. Infuse daily for 3 – 5 days during oestrus.
Note: Veterinarians are referred to the chapter antibioticsby W. M. Pedersoli (1983.Current Therapy in Equine Medicine Ed. Robinson, Pub. Saunders Co. pg 43 , 57) for a comprehensive review of antibiotic therapy in the horse and Gentamicin.
2.0 – 2.5 g per day to be administered by intra-uterine injection for 3 to 5 days during estrus. Each dose should be diluted with 200 – 500 ml of sterile physiological saline before aspetic uterine infusion.

Cows:
2 ml (200 mg) one time only. The dose should be diluted with 16ml sterile physiological saline solution before aspetic uterine infusion. Although GEN 10 is not spermicidal, treatment should not be given the day of breeding.

Clean and sterilize needles and syringes by boiling in water for 15 minutes prior to use. Disinfect the injection site and top of the bottle with a suitable disinfectant, such as 70% isopropyl alcohol.
Use all precautions to prevent contamination of vial contents.

STORAGE:
The product should be stored at room temperature (15°-30°C). GEN 10 is heat stable and does not require refrigeration. Protect from light.

CAUTION:
Do not use in animals that show or have shown sensitivity to gentamicin. Caution should be used when treating pregnant animals.

WARNING:
Chickens injected with GEN 10 Injection must not be slaughtered for food for at least five (5) weeks following treatment. Turkeys injected with GEN 10 Injection must not be slaughtered for food for at least nine (9) weeks following treatment. Piglets injected with GEN 10 must not be slaughtered for use in food for at least 42 days following treatment. Cows injected with GEN 10 must not be slaughtered for food for at least 30 days following treatment. Horses injected with GEN 10 must not be slaughtered for food.

PRESENTATION:
100 mL in clear glass vial.

SPECIES: cats, dogs, equine, livestock

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